Publication in Organic Letters
TAKASAGO has published a paper entitled "Formal Deoxygenative Hydrogenation of Lactams Using PNHP-Pincer Ruthenium Complexes under Nonacidic Conditions" in Organic Letters.
Org. Lett. 2019, 21, 9954-9959
https://pubs.acs.org/doi/10.1021/acs.orglett.9b03878
Here, we have reported the synthesis of cyclic amines using our catalyst, Ru-MACHO® series. Generally, stoichiometric amount of hydride reagents are used for reduction of lactams to cyclic amines. In this method, hazardous workup and large amount of waste can be a problem. In contrast, hydrogen gas, which is easy to handle, can be used as a reagent and water is the only side-product in our method, which makes the process safe, environmentally benign and efficient.